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Dr. Will Caster (Johnny Depp), the world's foremost authority on artificial intelligence, is conducting highly controversial experiments to create a sentient machine. When extremists try to kill the doctor, they inadvertently become the catalyst for him to succeed. Will's wife, Evelyn (Rebecca Hall), and best friend, Max (Paul Bettany), can only watch as his thirst for knowledge evolves to an omnipresent quest for power, and his loved ones soon realize that it may be impossible to stop him.